The Latest Breaking News from ClinicalTrialsgov

Deleting One Gene Kept Cancer-Fighting T Cells From Burning Out in St. Jude Mouse Studies of Immunotherapy

St. Jude scientists found that deleting the ZMYND8 gene kept T cells from becoming exhausted in mice. What it could mean for immunotherapy and what remains unproven.

Medical Daily · Sep 25

Global Dementia Trials Testing 158 Therapies May Need 350,000 Volunteers Because Strict Screening Turns Many Away

Dementia trials testing 158 therapies may need 350,000 volunteers to fill about 55,000 spots. Where U.S. families can search for trials and what to ask.

Medical Daily · Sep 22

Common Seizure Drug Levetiracetam Slowed Deadly Childhood Brain Tumors in Lab Models and Was Tied to Longer Survival

Common Seizure Drug Levetiracetam Slowed Deadly Childhood Brain Tumors in Lab Models and Was Tied to Longer Survival

Medical Daily · Sep 18

Earthquake Survivors Recorded 60 Seconds of Their Own Laughter and Played It Back Three Times a Day

Twenty survivors of the 2023 earthquakes recorded their own laughter and replayed it daily. Well-being scores rose, but there was no control group.

Medical Daily · Aug 31

Most Patients with Chronic Illness Would Join a Clinical Trial, but Two-Thirds Say Doctors Never Mention Them

Most patients say they would join a clinical trial, but two-thirds say a doctor never raised it. Here is what actually blocks enrollment.

Medical Daily · Aug 20

Researchers Identify an Ancient Immune Protein That May Explain Why Some Tumors Resist Checkpoint Drugs

Complement C3 produced within tumors kept immunosuppressive cells out and improved checkpoint immunotherapy response in mice, researchers report.

Medical Daily · Aug 10

Light-Activated Compounds Designed to Stand In for Lost Photoreceptors Restore Visual Behavior in Blind Animals

Barcelona-led researchers developed prosthe6, light-switchable molecules that substituted for lost photoreceptors and restored visual responses in mice.

Medical Daily · Aug 5

An Aging Protein Called EPS8 Drives Toxic Protein Clumping in ALS and Huntington's Models, Cologne Team Reports

Cologne researchers found the aging protein EPS8 drives toxic protein clumping in worm and human cell models of ALS and Huntington's disease.

Medical Daily · Aug 4

VA Launches a Randomized Trial Testing Whether Semaglutide Can Reduce Drinking in Veterans

The VA opened enrollment in CRAVE, a placebo-controlled trial of semaglutide for alcohol use disorder in more than 600 veterans at 18 medical centers.

Medical Daily · Aug 4

Fifteen volunteers spent 40 days inside a French cave without clocks, sunlight or phones and emerged believing only 30 days had passed

On March 14, 2021, fifteen volunteers, seven women and eight men aged between 27 and 50, entered the Lombrives cave in the French Pyrenees to begin a 40-day experiment with no clocks, no phones, no natural light and no contact with the outside world. Known as Deep Time, the project…

The Times of India · Aug 4