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Medical Daily
Medical Daily
Health
Elena Vega

Lancet Publishes Full Petrelintide Trial: About 10% Weight Loss, Nausea in 20% as Amylin Drug Enters Phase 3

Update Note: This article reports new information involving the experimental weight-loss drug petrelintide following MedicalDaily's earlier coverage. The newest data come from the peer-reviewed trial paper published September 29, 2026, in The Lancet Diabetes & Endocrinology and presented at the EASD annual meeting in Milan on September 30, 2026.

Full, peer-reviewed results for petrelintide, an experimental once-weekly amylin injection, show that adults with excess weight lost between 8.7% and 10.7% of their body weight over 42 weeks, compared with 1.7% on placebo. Nausea was reported by 20% of people on the drug vs. 6% on placebo. The findings were published in The Lancet Diabetes & Endocrinology.

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