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Canan Karakoç, Postdoctoral Scholar in Biological Sciences, Georgia Institute of Technology

Hibernating bacteria can invade hospitals and survive outer space – but their high energy bill is a weakness that scientists can strike

_Bacillus subtilis_ produces near-indestructible spores. Doc. RNDr. Josef Reischig, CSc./Wikimedia Commons, CC BY-SA

A spore is a bacterium’s survival capsule: dried almost solid, wrapped in protein armor and chemical processes shut down. Bacteria enter this state of hibernation when environmental conditions are unfavorable. What’s left is close to indestructible: It can survive boiling, desiccation, radiation and the vacuum of space. NASA once bolted Bacillus spores to the outside of a satellite and left them in orbit for nearly six years; the ones shielded from sunlight were able to come back to life upon returning to Earth.

Out in the dirt, bacteria have handed this spore-forming ability down for roughly 3 billion years. But if you put this bacterium in a comfortable laboratory flask and feed it well, within a few thousand generations it will lose the ability to make spores altogether.

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