GLP‑1 Peptides Cause Lean Muscle Loss—Study Finds Users Lose About 1.9 Pounds of Muscle (25% of Weight Lost)

The latest GLP-1 Peptide studies link it to loss of muscle mass – Pexels

For many people taking GLP-1 medications like Ozempic, Wegovy, or Zepbound, the number on the scale finally starts moving in the right direction. But newer research is raising a tougher question: what exactly is being lost besides fat? Some studies suggest that about 25% of weight lost on GLP-1 therapy may come from lean mass, including muscle. That does not mean these drugs are unsafe, but it does mean muscle health deserves more attention.

Why Muscle Loss Matters During GLP-1 Weight Loss