St. John's Wort is an herbal supplement known for its potential benefits in managing mild to moderate depression and anxiety. This plant-based remedy, scientifically called Hypericum perforatum, has been used for centuries in traditional medicine. It is believed to work by increasing levels of serotonin, dopamine, and other neurotransmitters in the brain, which can improve mood and overall well-being.
Benefits:
1. Mood Enhancement: St. John's Wort is widely recognized for its ability to alleviate symptoms of mild to moderate depression, potentially acting similarly to some antidepressants by increasing serotonin and dopamine levels. A 2017 meta-analysis of 27 studies found that St. John's Wort was more effective than a placebo and nearly as effective as standard antidepressants in treating mild to moderate depression.
2. Anxiety Relief: The supplement may also help reduce anxiety and improve emotional stability, making it useful for those dealing with stress-related conditions. A 2013 study suggested that St. John's Wort could be effective in reducing symptoms of anxiety, though more research is needed to confirm these findings.
3. Improved Sleep Quality: By regulating mood and anxiety, St. John's Wort can contribute to better sleep patterns, helping those who suffer from insomnia or disturbed sleep.
4. Seasonal Affective Disorder (SAD): It's particularly beneficial for those experiencing Seasonal Affective Disorder, a type of depression that occurs during specific seasons, usually winter.
5. Menopausal Symptoms: Some evidence suggests that St. John's Wort may help ease menopausal symptoms, including mood swings and hot flashes, offering a natural alternative to hormone replacement therapy. A 2010 study found that St. John's Wort, especially when combined with black cohosh, could significantly reduce menopausal symptoms .
Side Effects: Despite its natural origins, St. John's Wort can have side effects, including dry mouth, dizziness, gastrointestinal symptoms, and fatigue. It can also increase sensitivity to sunlight and interact with various medications, such as antidepressants, birth control pills, and blood thinners.
Dosage: The typical dosage for St. John's Wort is 300 mg taken three times daily. However, this may vary based on individual needs and the specific formulation of the supplement. It's important to start with a lower dose and gradually increase it, under the guidance of a healthcare professional.
Here are the best St John's Wort Supplements based upon reviews
Nature's Way St. John's Wort Herb
Nature's Way St. John's Wort offers 700 mg of St. John's Wort per serving to support a positive outlook. This gluten-free, vegan supplement is free from artificial additives and is Non-GMO Project Verified. For optimal results, take two capsules twice daily and continue use for at least two months. Nature's Way has been crafting quality vitamins and supplements inspired by nature for over 50 years.
2. Horbäach St John's Wort Capsules 300mg
Horbaach St. John's Wort features 300 mg of this traditional herb in quick-release capsules designed for convenience. This advanced formula is crafted with a focus on purity and potency, ensuring high-quality supplementation. Free from gluten, artificial additives, and GMOs, it caters to those with specific dietary needs. Backed by Horbaach's commitment to superior quality, this product is laboratory-tested and 100% guaranteed for effectiveness.
3. Toniq St. John's Wort Capsules
Toniq St. John's Wort Capsules deliver 1,000 mg of high-quality St. John's Wort powder per serving, offering one of the highest concentrations of hypericin for potent health benefits. The supplement is made from ethically sourced ingredients, using a 7:1 extraction process for maximum efficacy. Produced in a GMP-certified, NSF-approved facility in the USA, each batch undergoes rigorous testing for purity and active ingredient levels. Toniiq ensures the highest quality by testing both in-house and through third-party laboratories.
4. Zazzee Extra Strength St. John's Wort
This Extra Strength St. John's Wort Extract offers 8000 mg per capsule, delivering one of the most potent formulas available with a 20:1 extract ratio. With 150 capsules per bottle, it provides a 5-month supply, making it an exceptional value. The extract is standardized to contain a minimum of 0.3% Hypericin, ensuring maximum potency. Made from 100% vegan, non-GMO ingredients, it is free from common allergens and manufactured in a USA-based facility with strict quality control.
5. Nature's Bounty St. John's Wort 300mg
Nature's Bounty St. John's Wort offers daily mood support with 900 mg per serving, helping to maintain a positive outlook and emotional well-being. This supplement is standardized to contain 0.3% Hypericin, ensuring consistent quality and potency. It is made with pure, non-GMO ingredients, free from sugar, gluten, lactose, and artificial additives. Backed by nearly 50 years of expertise, Nature's Bounty delivers a trusted herbal calm aid to support relaxation and tranquility.
6. NOW Supplements, St. John's Wort
NOW St. John's Wort capsules provide a standardized extract with 0.3% Hypericin, ensuring consistent potency and quality. These vegan, non-GMO capsules are free from common allergens like soy, gluten, dairy, and nuts, making them suitable for various dietary needs. Produced in a GMP-certified facility, NOW ensures high standards in manufacturing, including rigorous testing for stability and potency. Packaged in the USA by a trusted, family-owned company since 1968, this supplement offers a reliable option for herbal support.
7. Clean Nutraceuticals St Johns Wort
Clean Nutra's Positeava combines St. John's Wort with Rhodiola, Ashwagandha, and Holy Basil in a potent all-in-one supplement designed for mood support. This advanced formula offers the benefits of four full-dose products in just three capsules, providing a convenient alternative to multiple supplements. It also includes Vitamin C and Black Pepper for enhanced absorption, making it a powerful addition to your wellness routine. Proudly made in a certified facility, Positeava ensures trusted quality and efficacy.
8. Healths St. John's Wort
Healths Harmony St. John's Wort capsules provide a potent 900 mcg of Hypericin per serving for effective mood support. Each bottle contains 120 capsules, with a simple one-capsule serving, making it easy to incorporate into your daily routine. Manufactured in a GMP-certified facility in the USA, these non-GMO capsules ensure high quality and purity. With a standardized 0.3% Hypericin extract, this supplement offers a reliable and convenient way to experience the benefits of St. John's Wort.
9. Gaia PRO St. John's Wort
Gaia PRO St. John's Wort provides 1,350 mg of concentrated extract from fresh flowering buds in each daily serving, delivering 2.7 mg of Hypericins. This dosage aligns with research supporting nervous system health and positive mood. The supplement is crafted from high-quality, fresh St. John's Wort to ensure potency and effectiveness. Designed for professionals, Gaia PRO offers a reliable option for those seeking herbal support for emotional well-being.
10. Nutricost St John's Wort Capsules
Nutricost St. John's Wort Capsules offer 500 mg of St. John's Wort per capsule, providing a simple and effective way to support your mood and emotional well-being. Each bottle contains 120 vegetarian capsules, with St. John's Wort as the sole active ingredient, ensuring focused herbal support. These capsules are non-GMO, gluten-free, soy-free, and third-party tested for quality assurance. Manufactured in a GMP-compliant, FDA-registered facility, Nutricost delivers a trustworthy and high-quality supplement option.
11. SOLARAY St. John's Wort Aerial Extract
This brain support supplement provides 900 mg of St. John's Wort Extract per tablet, standardized to 0.3% Hypericin for mood enhancement and stress support. It's designed to help maintain healthy brain function and a positive outlook, making it ideal for managing mood fluctuations. Packaged in eco-friendly bottles made from ocean and landfill plastics, this product aligns with sustainable practices. Manufactured in a GMP-certified facility, it comes with a 60-day money-back guarantee, ensuring quality and satisfaction.
12. NatureBell St Johns Wort 9,000mg
NatureBell's Max Strength St. John's Wort capsules deliver a potent 9,000 mg herbal equivalent in each serving, derived from a 15:1 extract of Hypericum Perforatum. With 240 easy-to-swallow capsules, this supplement provides a 120-day supply for consistent support of a positive mood and well-being. Sourced naturally in North America, these non-GMO capsules are free from common allergens and are third-party lab tested for safety and potency. Designed for both men and women, they offer high-quality, plant-based wellness support.
13. Satoomi St. John's Wort Capsules
Satoomi St. John's Wort is a plant-based herbal supplement designed to support mood, restful sleep, and immune health. Each capsule contains a blend of six powerful herbal ingredients, including St. John's Wort, Ashwagandha, Turmeric, and Ginkgo Biloba, providing a comprehensive wellness solution. With 90 capsules per bottle, it offers a 3-month supply for daily support. Manufactured in India, this vegan-friendly supplement is made using advanced extraction technology and meets strict GMP and ISO standards for quality.
14. Herbal Roots St. John's Wort
Herbal Roots St. John's Wort is an extra-strength supplement featuring a standardized extract combined with pure organic St. John's Wort flower for optimal mood and nervous system support. This supplement is made without binders, fillers, or additives, ensuring a pure and potent formula. Manufactured in a facility certified by Good Manufacturing Practices (cGMP) and third-party tested, it meets high-quality standards. Herbal Roots is a small, family-owned, women-operated company dedicated to providing trusted, natural wellness products.
15. DEAL SUPPLEMENT St. John's Wort Extract 1000mg
DEAL SUPPLEMENT St. John's Wort Extract provides a potent 1,000 mg dose per serving, derived from naturally grown flower heads in North America. Each serving is standardized to contain 3,000 mcg of active Hypericins, promoting mental calmness and relaxation throughout the day. With 240 capsules in total, this supplement offers a 120-day supply, making it an excellent choice for daily stress relief. It is non-GMO, third-party lab tested, and free from common allergens, ensuring a high-quality, pure formula.
16. NusaPure St. John's Wort 6,000mg
NusaPure St. John's Wort provides a potent 6,000 mg equivalent per serving, thanks to a 10:1 extract for maximum effectiveness. Each serving contains a minimum of 1,800 mcg of Hypericin, a key active compound, and comes in convenient 240 veggie capsules, offering a 120-day supply. This advanced supplement is vegan-friendly, made with high-quality ingredients, and manufactured in a cGMP-registered facility to ensure superior quality. It's an ideal choice for those seeking natural support for mood and well-being.
17. Herb Pharm St. John's Wort Liquid Extract
Herb Pharm St. John's Wort Liquid Extract is designed to support a positive mood and maintain emotional balance. This easily absorbed liquid engages your senses of taste and smell, enhancing the effectiveness of the herbs. It is made from sustainably wildcrafted Hypericum perforatum plants, using only the fresh flowering and budding tops. The extract is vegan, non-GMO, and gluten-free, with herb identity assured through rigorous testing methods.
18. Bronson St. John's Wort 700 MG
Bronson St. John's Wort 700 MG provides a potent 700 mg dose per serving, sourced from a 7:1 extract to support a healthy mood. This traditional herb, Hypericum perforatum, has been used for centuries to promote a positive outlook. The supplement is vegan-friendly, and free from GMOs, gluten, and soy, with each batch laboratory tested for purity. Manufactured in a state-of-the-art facility in Hauppauge, New York, Bronson ensures that all products meet rigorous cGMP standards for quality and safety.
19. Carlyle St John's Wort Capsules
Carlyle St. John's Wort Capsules offer a standardized extract equivalent to 4800 mg of St. John's Wort per serving, harnessing the benefits of the herb's naturally occurring antioxidant flavonoids. These capsules are crafted to support your journey to wellness with premium, honest supplements. The product is free from gluten, wheat, yeast, milk, lactose, artificial flavors, sweeteners, and GMOs. Each batch is laboratory tested to ensure superior quality and 100% satisfaction.
20.Horbäach St Johns Wort Tincture
Horbäach St. John's Wort Tincture features a super-concentrated, alcohol-free liquid extract derived from the blossoming yellow flower rich in antioxidant flavonoids. This vegetarian formula ensures purity and potency, crafted with a commitment to high standards. The tincture is free from gluten, wheat, yeast, milk, lactose, artificial flavors, sweeteners, and GMOs. Each batch is laboratory tested to guarantee superior quality and effectiveness.
21. Oregon's Wild Harvest St John's Wort Supplement
Oregon's Wild Harvest St. John's Wort Supplement is designed to help lift your spirits and support a positive mood. This product is free from artificial flavors, colors, excipients, or stearates, ensuring a pure and natural formulation. Verified Non-GMO by SGS, a third-party independent lab, it meets high standards for quality. Made with care in Redmond, OR, the supplement may arrive warm during summer, but Amazon ensures proper storage and shipping in accordance with manufacturer recommendations.
22. Tinies bers St. John's Wort Gummies
Tinies bers St. John's Wort Gummies deliver 500 mg of herbal nutrients per serving, sourced from the aerial parts of the plant and standardized to 0.3% Hypericin. These sugar-free gummies use xylitol to provide a sweet taste without traditional sugars or sugar coatings. Suitable for both adults and kids, they are vegan, pectin-based, non-GMO, and gluten-free. With a soft texture and lemon flavor, these GMP-compliant, lab-tested gummies offer stress relief and support brain health.
23. Natures Plus Herbal Actives St John's Wort
This natural St. John's Wort supplement delivers consistent potency with 0.3% - 0.5% hypericin (1.35 mg - 2.25 mg) per tablet, ensuring effective activity. The extended-release formulation provides maximum efficiency through controlled delivery. Made in state-of-the-art facilities, the product adheres to cGMP compliance and is both FDA and NSF registered. Each bottle contains 60 tablets, offering a full 60 servings of this hypoallergenic, gluten-free, vegetarian, and vegan supplement.
24. Vitanica St. John's Wort Capsules
Vitanica St. John's Wort Capsules support a positive outlook and may benefit women dealing with PMS or menopause symptoms. Each capsule contains 300 mg of St. John's Wort extract, standardized to 0.3% hypericin, plus 100 mg of whole flowering tops, blending scientific research with traditional use. The product uses high-quality, non-GMO, and vegan ingredients, and is rigorously tested for quality, purity, and identity. Manufactured in state-of-the-art USA facilities, Vitanica's capsules are trusted by customers and doctors for their excellence and adherence to GMP standards.
25. Earthborn Elements St. John's Wort
Earthborn Elements St. John's Wort Capsules provide pure, undiluted herbal support with no additives or fillers. This supplement features St. John's Wort, a flowering herb native to Europe, western Asia, and North Africa. Each bottle offers a 100-day supply, ensuring over three months of consistent health support. Encapsulated in the USA, this product adheres to high standards of purity and quality.
