New database research points to something women with repeat urinary tract infections have rarely been told: a low-dose cream, tablet, or ring applied locally is associated with fewer trips to the hospital, fewer episodes of sepsis, and lower death rates over the following years.
The analysis, titled "Vaginal Estrogen Prescription is Associated with Reduced Rates of Serious Adverse Outcomes in Women of All Age Groups With Recurrent Urinary Tract Infection," was published online in the journal Urology on July 1, 2026, and drew on the Epic Cosmos database of electronic health records. An accompanying editorial comment was published alongside it.
