Eleven people have been killed, including two children, after a Russian missile hit Ukraine's northeastern city of Sumy, officials said.
Eighty-nine people, including 11 children, were also injured in the attack on the city late on Sunday, Ukraine's state emergency service said via the Telegram messaging app.
The attack on Sumy followed a morning of Russia pounding Ukraine's power grid in what Kyiv said was a "massive" attack with 120 missiles and 90 drones that killed at least seven people.
The strikes come hours after US President Joe Biden authorised Ukraine's use of US-supplied long-range missiles to strike inside Russia for the first time.
Western supporters had previously said the US ban had made it impossible for Ukraine to try to stop Russian attacks on its cities and electrical grids.
The move marks a major US policy shift, just as Mr Biden is about to leave office, and has led to criticism from his opponents - including Donald Trump Junior who said using the missiles could spark World War III.
"Sunday evening for the city of Sumy became hell, a tragedy that Russia brought to our land," Volodymyr Artyukh, the head of the Sumy military administration said in a post on the administration's Telegram messaging channel.
The military administration said another missile hit critical infrastructure, leaving the city without power.
Ukraine's air force said that Russian forces used two Iskander-M ballistic missiles and a Kh-59 guided missile in the overnight attack.
Rescuers and all necessary services continued to work at the scene and psychologists were providing assistance to those affected, the State Emergency Service of Ukraine said on Telegram.
More than 400 people were evacuated, the Service added.
Photographs posted on Telegram by State Emergency Service of Ukraine showed firefighters battling a blaze consuming cars and rescuers carrying people out of a building. One image showed a multi-storey building with nearly all windows blown out and its facade damaged.
Sumy regional prosecutors said the attack damaged 90 apartments, 28 cars, two educational institutions and 13 buildings.
There was no immediate comment from Moscow.
Both sides deny targeting civilians in their strikes on each other's territory. But thousands have died since early 2022 in Russia's full-scale invasion of Ukraine, the vast majority of them Ukrainians.
