Tottenham will be without both Micky van de Ven and Pedro Porro tonight.
While it is hoped that the centre-back will be back this weekend, the right-back has been ruled out for a month with a hamstring injury.
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In more positive news, Spurs have been boosted by the returns of Joao Palhinha and Pape Matar Sarr in midfield. With Conor Gallagher and Yves Bissouma ineligible against Frankfurt, Spurs are stretched for options in the centre of the park.
So the sight of Palhinha, who has missed Spurs’ last three games, and Africa Cup of Nations winner Sarr in training on Tuesday will have come as a welcome relief for Frank.
Randal Kolo Muani and Wilson Odobert should also be available for selection after travelling to Frankfurt later than planned after a minor car accident.
Radu Dragusin, new £13million signing Souza and Mathys Tel are also ineligible, with Dominic Solanke taking Tel’s place in Spurs’ Champions League squad last week.
James Maddison, Dejan Kulusevski, Rodrigo Bentancur, Mohammed Kudus, Lucas Bergvall, Ben Davies and Richarlison remain out as Spurs, who have 14 senior players unavailable in total, look to seal automatic qualification for the Champions League last 16.
They travel to Frankfurt knowing that a win will see them avoid a nervy two-legged knockout play-off tie.
Confirmed team news
Frankfurt XI: Kaua Santos; Buta, Amenda, Koch, Theate, Brown; Hojlund, Skhiri, Larsson; Gotze, Knauff
Subs: Zetterer, Grahl, Chaibi, Kristensen, Dahoud, Bahoya, Doan, Chandler, Collins, Doumbia, Dills
Tottenham XI: Vicario; Spence, Romero, Danso, Udogie; Palhinha, Gray; Odobert, Sarr, Simons; Kolo Muani
Subs: Kinsky, Austin, Solanke, Scarlett, Olusesi, Kyerematen, Hardy, Byfield, Rowswell, Hall
Injured: Maddison, Kulusevski, Bentancur, Kudus, Richarlison, Davies, Bergvall, Porro, Van de Ven
Ineligible: Tel, Gallagher, Dragusin, Bissouma, Souza
Time and date: 8pm GMT on Wednesday January 28, 2026
Venue: Deutsche Bank Park, Frankfurt
How to watch: TNT Sports
