Updated on March 11, 2026: Our Slay the Spire 2 Character Tier List has been updated with new sections covering the best cards for every character, including The Defect. We've also made adjustments to the best cards and relics cross-references for The Silent and The Ironclad, and we will continue to update this guide as the game evolves during Early Access.
Slay the Spire 2 is finally here, and if you've already been crushed by a random Act 1 elite you were absolutely confident you could handle, you're in good company. Mega Crit's sequel to the genre-defining roguelike deckbuilder brings back three beloved characters alongside two completely new ones. Ranking all five in the current meta is no small task this early into Early Access — but here's our Slay the Spire 2 character tier list, based on everything the community and we have learned since launch. If you're also looking for what to pick up along the way, check out our Slay the Spire 2 Relics Tier List for a full breakdown of every relic worth taking.
