David Moyes is expected to make changes to his side that put in an excellent, albeit fruitless, performance against Liverpool on the weekend with Declan Rice set to return to the side.
Rice missed out at Anfield after contracting a virus but the Hammers key midfielder is set for a return to the starting XI in Seville this evening.
Moyes was positive over Rice's availability for the last-16 clash with the manager saying: "He trained today for the first time. He did not train yesterday. He was very unwell but he is with us and if fit and available he will certainly play.," during his pre-match press conference on Wednesday.