Trimethylglycine (TMG), also known as betaine, is a naturally occurring compound found in various foods, including beets, spinach, and whole grains. This nutrient is gaining attention for its numerous health benefits, particularly in promoting heart health and supporting overall well-being. As research continues to uncover the potential of TMG, it's important to understand how it works and why it might be a valuable addition to your health regimen.
What is Trimethylglycine (TMG)?
Trimethylglycine is a derivative of the amino acid glycine, characterized by its three methyl groups. These methyl groups play a crucial role in methylation, a biochemical process that is vital for various bodily functions, including DNA synthesis, liver detoxification, and neurotransmitter regulation. As a methyl donor, TMG helps to convert homocysteine—a potentially harmful amino acid—into methionine, an essential amino acid involved in protein synthesis and other metabolic processes.
TMG is naturally present in many foods, but it is also available as a dietary supplement. Given its role in methylation and homocysteine metabolism, TMG has been studied for its potential health benefits, particularly in cardiovascular health and liver function.
How Does TMG Work?
TMG's primary role in the body is as a methyl donor, contributing to the process of methylation. Methylation is critical for many physiological processes, including gene expression, protein function, and the detoxification of harmful substances. By donating a methyl group to homocysteine, TMG helps to convert it into methionine. Elevated levels of homocysteine are associated with an increased risk of cardiovascular disease, so maintaining proper levels through methylation is essential for heart health.
Additionally, TMG's involvement in methylation supports the production of S-adenosylmethionine (SAMe), a compound that plays a role in mood regulation, liver health, and joint function. This multifaceted role of TMG makes it a key player in maintaining overall health and well-being.
Benefits of TMG
- Supports Heart Health: One of the most well-known benefits of TMG is its ability to help maintain healthy homocysteine levels. Elevated homocysteine is a recognized risk factor for cardiovascular diseases, including heart attacks and strokes. By converting homocysteine to methionine, TMG helps protect the cardiovascular system, potentially reducing the risk of heart-related conditions. A study published in the American Journal of Clinical Nutrition found that supplementation with TMG significantly lowered plasma homocysteine concentrations, highlighting its role in cardiovascular protection.
- Enhances Liver Function: TMG is known to support liver health by promoting the detoxification process. It helps to metabolize and remove toxins from the liver, enhancing the liver's ability to process fats and prevent fatty liver disease. This detoxifying property makes TMG a valuable nutrient for individuals looking to support their liver function and overall metabolic health. Research published in the Journal of Hepatology demonstrated that TMG supplementation improved liver function and reduced fat accumulation in patients with non-alcoholic fatty liver disease (NAFLD), indicating its potential in supporting liver health.
- Improves Athletic Performance: Athletes and fitness enthusiasts are increasingly turning to TMG for its potential to enhance performance. TMG is believed to improve physical endurance and strength by promoting better muscle oxygenation and reducing fatigue. Its role in methylation also supports energy production and muscle recovery, making it a popular choice among those engaged in rigorous physical activities. A study featured in the Journal of the International Society of Sports Nutrition showed that athletes who supplemented with TMG experienced significant improvements in power output and endurance, suggesting TMG's beneficial role in enhancing athletic performance.
- Promotes Cognitive Health: TMG may have neuroprotective benefits due to its role in supporting the production of SAMe, a compound that influences neurotransmitter activity and brain function. Adequate levels of SAMe are associated with better mood regulation, cognitive function, and a reduced risk of depression. By supporting methylation, TMG contributes to maintaining mental clarity and cognitive health.
- Boosts Immune System: TMG's involvement in methylation also plays a role in immune function. Methylation helps regulate the expression of genes involved in immune response, which is essential for maintaining a healthy and balanced immune system. A robust immune system is vital for protecting the body against infections and illnesses.
1. NOW Foods TMG 1000 mg
NOW Foods TMG provides a potent dose of 1000 mg per tablet, making it ideal for supporting cardiovascular health and methylation processes. The formula is vegetarian and free from common allergens. It's an excellent choice for those seeking a high-quality, affordable TMG supplement.
2. ProHealth Longevity | TMG Supplements
ProHealth TMG (Trimethylglycine) is designed to support the body's methylation processes, which are essential for DNA repair, energy production, and liver detoxification. By promoting healthy homocysteine levels, this supplement helps maintain cardiovascular health and provides age-defying benefits by replenishing the body's methyl pool. Recommended by longevity experts and trusted for over 33 years, ProHealth TMG is a reliable choice for enhancing overall wellness.
3. Life Extension TMG 500 mg
Life Extension TMG provides 500 mg of TMG per capsule, supporting cardiovascular health and liver function. Its formula is designed to optimize methylation and promote detoxification processes. The supplement is non-GMO and easy to incorporate into daily routines.
4. Kirkman TMG
Kirkman TMG supports cardiovascular health and enhances the immune system by aiding methylation and methionine metabolism. This hypoallergenic supplement is safe for daily use and helps soothe adrenal glands during times of stress. Manufactured under Kirkman's Ultra Tested standards, it ensures pure quality free from common allergens.
5. NexGen Blends TMG Complex
NexGen Blends TMG is an advanced methylation support supplement that combines TMG with essential methyl factors like 5-MTHF, Methylcobalamin B12, and P5P vitamin B6 to enhance the conversion of homocysteine to methionine. This powerful blend supports cognitive function, heart health, liver detox, and overall peak performance by promoting effective methylation at the molecular level.
6. BulkSupplements.com TMG Powder
This Trimethylglycine (TMG) powder offers a potent 1500mg dose per serving, ideal for supporting strength, performance, and an active lifestyle. Its versatile, unflavored formula is free from unnecessary allergens, making it easy to mix into shakes or beverages and suitable for a variety of dietary needs. Produced in a cGMP-compliant facility and rigorously third-party tested, this TMG supplement ensures high-quality, trustworthy support for your fitness and health goals.
7. Puregen Labs TMG 750 mg
Puregen Labs TMG Vegetarian capsules deliver 750mg of high-quality Trimethylglycine per capsule to support healthy homocysteine levels and cardiovascular function. This supplement promotes liver health by potentially inhibiting inflammatory factors, thanks to its betaine content. Made in a cGMP-certified facility in the USA, the capsules are easy to swallow and free from gluten, wheat, milk, lactose, artificial flavors, sweeteners, and colors, ensuring a pure and reliable choice for health support.
8. Nutricost TMG 500 mg
Nutricost TMG offers a straightforward, effective supplement with 500 mg of TMG per capsule, supporting heart health and detoxification. It's non-GMO, gluten-free, and tested for purity and potency. Nutricost provides a simple, affordable solution for those looking to support their methylation pathways.
9. Double Wood Supplements TMG Trimethylglycine Supplement
Double Wood's TMG capsules are a genuine product, characterized by a fishy odor that indicates authenticity. Designed to support athletic performance, TMG may enhance muscle oxygenation and training volume. Supplementing with TMG has been shown to potentially reduce homocysteine levels by up to 40%, and it pairs well with methylated multivitamins for optimal cardiovascular health. Manufactured in the USA with globally sourced, non-GMO, and gluten-free ingredients, this supplement ensures quality and purity.
10. Thorne Research Methyl-Guard Plus
Thorne Research Methyl-Guard Plus combines TMG with folate and B vitamins to optimize methylation and homocysteine metabolism. This comprehensive formula supports cardiovascular, neurological, and liver health. It's free from gluten, soy, and dairy, catering to those with dietary restrictions.
11. Source Naturals TMG 750 mg
Source Naturals TMG provides 750 mg of TMG per tablet to support methylation and homocysteine conversion. The product is suitable for vegetarians and is free from gluten, yeast, and dairy. It's an effective supplement for those seeking enhanced cardiovascular and liver health.
12. GENEX 1000mg TMG
Genex Trimethylglycine, derived from glycine, offers a natural source of TMG to optimize overall well-being. Available in 500mg and 1000mg dosage options, it provides flexibility to meet individual needs and comes in a 30-day supply for consistent use. Manufactured in a GMP-certified facility, the supplement is non-GMO, vegan-friendly, gluten-free, and free from common allergens, ensuring high quality and broad dietary compatibility.
13. Solgar Homocysteine Modulators
Solgar's Trimethylglycine supplement features a special blend of antioxidants, PhytO2X, to ensure ingredient freshness. Suitable for vegans and made from non-GMO ingredients, it reflects Solgar's commitment to high-quality, plant-based formulations. The product is certified gluten-free, free from common allergens and artificial additives, and bears KOF-K Kosher certification, adhering to strict kosher laws.
14. NutraBio TMG 750 mg
NutraBio TMG delivers 500 mg per capsule, supporting liver detoxification and cardiovascular health. This supplement is free from fillers, excipients, and artificial ingredients. It's an excellent choice for those seeking a high-quality, pure TMG product.
15. Allergy Research Group TMG Trimethylglycine 750mg Supplement
Allergy Research Group's Trimethylglycine supplement supports healthy methylation by acting as an osmolyte and methyl-group donor, particularly beneficial when folate levels are deficient. Each vegetarian capsule delivers 750 mg of high-quality TMG, with recommended use of 1 to 3 capsules daily before meals. Developed by doctors and manufactured with stringent quality control, this hypoallergenic supplement ensures purity and effectiveness for optimal health support.
16. VAITE TMG Supplements
This TMG supplement offers 1000mg of trimethylglycine per serving to support healthy homocysteine levels and overall wellness, with the convenience of just one gummy a day. Fortified with essential B vitamins, these plant-based gummies provide comprehensive nutritional support in a delightful, vegan-friendly format. Designed for optimal absorption, they ensure effective nutrient uptake, promoting long-term vitality and a balanced, active lifestyle with every chewable gummy.
17. 10X Health TMG Supplements
10X TMG Trimethylglycine supplement, formulated with glycine betaine, supports optimal homocysteine levels, crucial for cardiovascular health. This potent amino acid aids in liver and heart cleansing and helps address disruptions in the methylation cycle, promoting overall wellness. Additionally, it boosts energy and vitality by enhancing mitochondrial function, and is made with premium ingredients, ensuring quality and safety for those seeking to enhance their health.
18. Puregen Labs TMG 750 mg
Puregen Labs TMG Vegetarian capsules deliver 750mg of high-quality Trimethylglycine per capsule, supporting healthy homocysteine levels and cardiovascular function. Trimethylglycine, also known as Betaine, may promote liver health by inhibiting inflammatory factors. Manufactured in a cGMP-certified facility in the USA, these easy-to-swallow capsules are free from gluten, wheat, milk, lactose, artificial flavors, sweeteners, and colors, ensuring a natural and reliable supplement.
19. Earthborn Elements TMG Betaine Anhydrous Trimethylglycine
Earthborn Elements offers 200 TMG Betaine Anhydrous Trimethylglycine capsules, providing pure and undiluted Trimethylglycine without additives or fillers. This 100-day supply ensures over three months of consistent support for peak health. Encapsulated in the USA, these capsules are designed to deliver high-quality, effective supplementation.
20. Vitamatic TMG Supplements
Vitamatic TMG delivers 1000 mg of TMG per capsule, supporting homocysteine metabolism and liver function. This supplement is gluten-free and non-GMO, ensuring purity and safety. It's a cost-effective option for those looking to maintain heart health and detoxification.
21. Pure Original Ingredients TMG Trimethylglycine
Pure Original Ingredients TMG Trimethylglycine Capsules offer a single-ingredient formula for a pure, undiluted supplement. With Trimethylglycine produced naturally in the body, this 50-day supply supports peak health with no additives, stearates, or rice fillers. Packaged in Utah, USA, these capsules ensure high-quality and effective supplementation.
22. Pure Original Ingredients TMG
TMG (Trimethylglycine) Capsules feature a single-ingredient formula for a pure, undiluted supplement. Produced naturally in the body, TMG supports overall health with no additives, stearates, or rice fillers. This 180-day supply offers six months of peak health support and is packaged in Utah, USA.
23. Carlyle TMG 1400mg
Carlyle TMG provides a potent 1400mg of Trimethylglycine per serving in a quick-release capsule, supporting optimal wellness. Naturally occurring in the body and in superfoods like beets, TMG is delivered in a premium, honest formula. Carlyle's supplements are laboratory tested for superior quality and are free from gluten, wheat, lactose, soy, artificial flavors, sweeteners, and are non-GMO.
24. Tuthi TMG Supplements
Tuthi TMG provides 1000mg of high-quality trimethylglycine per serving, supporting heart wellness by promoting healthy homocysteine levels with just 2 capsules daily. This supplement also aids athletic performance by enhancing muscle oxygenation, ideal for athletes seeking improved endurance. Proudly made in the USA, Tuthi TMG is non-GMO and gluten-free, crafted to support liver health and overall detoxification. Versatile in its benefits, it helps maintain healthy B vitamin levels and supports both cardiovascular and liver health, contributing to a balanced lifestyle.
25. Type Zero Clean TMG
This supplement delivers 750mg of trimethylglycine per serving, with each bottle containing 120 capsules for convenient daily use. It is manufactured in an NSF Certified GMP Compliant facility and undergoes rigorous third-party testing by independent ISO-accredited laboratories. Designed to seamlessly integrate into your daily wellness routine, it ensures quality and effectiveness.
