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International Business Times UK
International Business Times UK
Dani Oh

AI-Designed Rentosertib Raises Eyebrows as It Appears To Make Patients Biologically Younger in Small Trial

An analysis of 42 IPF patients found younger predicted biological-age profiles across six proteomic ageing clocks after Rentosertib treatment (Credit: Insilico Medicine/YouTube)

An AI-designed drug appeared to make patients biologically 'younger' across six different ageing clocks in a small trial of idiopathic pulmonary fibrosis, according to research published in Nature Biotechnology on 7 September 2026.

Rentosertib, an investigational TNIK inhibitor developed by Insilico Medicine, showed its clearest signal after four weeks at 30 mg twice daily in a secondary analysis of a Phase 2a study that was primarily designed to assess safety and tolerability.

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