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Mathieu Epardaud, Research Associate, Inrae

Advantages and challenges of anti-Covid nasal vaccination: the promises of a French approach

A team from the University of Tours and INRAE is working on the development of an innovative nasal vaccine against Covid, in spray form. LoValTech, Fourni par l'auteur

Contrary to the widely shared popular belief, the primary purpose of current vaccines against Covid-19 is solely to protect against serious forms of the disease in order to prevent the risk of hospitalisations and death… and not to block transmission between individuals. To do this, it would be necessary to aim for a so-called sterilising vaccination: only then could the circle of contamination be interrupted, allowing to stop the pandemic.

How to reach this level of efficacy? In general, vaccination allows the induction of an immune response based on two types of cells: T lymphocytes, capable of destroying infected cells, and B lymphocytes which produce antibodies capable of neutralising the virus (SARS-CoV-2 in the case of Covid) to prevent it from multiplicating and infecting new healthy cells.

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