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The Latest Breaking News from 49ers

49ers lose RBs Christian McCaffrey, Jordan Mason to IR

The injury-riddled 49ers lose Christian McCaffrey and Jordan Mason

USA Today Sports Media Group

49ers Turn to Rookie Starting RB As Christian McCaffrey, Jordan Mason Head to IR

Isaac Guerendo will start at running back for the 49ers with McCaffrey and Mason out.

Sports Illustrated

49ers injury update is bad news for 2 star running backs

Both of the 49ers top two running backs suffered injuries against the Bills on Sunday.

USA Today Sports Media Group

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read the most diverse news in one place.

Mic’d-up video showed Josh Allen’s hilarious exchange on the Bills sidelines after his epic receiving touchdown

"I love football."

USA Today Sports Media Group

Christian McCaffrey’s Dad Candidly Addresses 49ers RB's Future After Latest Knee Injury

The 49ers star suffered a potentially season-ending knee injury in Sunday's loss to the Bills.

Sports Illustrated

Which Team Has the Most Super Bowl Wins in History?

Some franchises have managed to reach the mountaintop over and over again.

Sports Illustrated

Buffalo Bills star leaves NFL fans baffled after arriving to game barefoot despite 23 inches of snow

The Buffalo Bills beat the San Francisco 49ers during their game in the snow on Sunday

The Independent UK

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A Bills fan actually tried throwing a snowball at a 49ers field goal attempt

Nice try.

USA Today Sports Media Group

Why NFL Week 13 results were so damaging for 49ers

The San Francisco 49ers' playoff hopes are fading fast.

USA Today Sports Media Group

Josh Allen and Sean McDermott made adorable snow angels after Bills’ snowy win

Snow angels for the win!

USA Today Sports Media Group

Isaac Guerendo Could Be Most Valuable Fantasy Football Asset Over Jordan Mason With Christian McCaffrey Injured

Isaac Guerendo and Jordan Mason are both top waiver wire adds this week with Christian McCaffrey hurt.

Sports Illustrated

Josh Allen Had Classy Answer About His Favorite TD in Win Against 49ers

The QB had a nice shoutout for a teammate.

Sports Illustrated

49Ers' Mccaffrey Suffers Potentially Season-Ending Knee Injury

San Francisco 49ers face challenges as running back Christian McCaffrey sustains a potentially season-ending knee injury.

Top News

Josh Allen Leads Bills To AFC East Title

Buffalo Bills QB Josh Allen shines in engagement and game, leading team to victory over 49ers with standout performance and dominant play.

Sports Illustrated

Bills' Amari Cooper Explains How Lateral TD to Josh Allen Came to Fruition

Amari Cooper explained his decision to lateral to Josh Allen during the Bills' surreal touchdown vs. the 49ers.

The Independent UK

Buffalo Bills clinch fifth straight AFC title in the snow

Josh Allen scored touchdowns passing, rushing and receiving as the Bills beat the San Francisco 49ers 35-10.

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Sports Illustrated

Josh Allen, Sean McDermott Gleefully Celebrate Bills Win vs. 49ers With Snow Angels

Josh Allen and Sean McDermott hit snow angels on the field in celebration of the Bills' Week 13 win.

Sports Illustrated

Christian McCaffrey Suffered Likely Season-Ending Knee Injury vs. Bills

San Francisco may have lost more than just a game on Sunday night.

USA Today Sports Media Group

Christian McCaffrey feared to have suffered season-ending knee injury

San Francisco 49ers running back Christian McCaffrey is feared to have suffered a season-ending PCL injury vs. the Buffalo Bills.

The Independent UK

Josh Allen has TDs passing, rushing and receiving as Bills rout 49ers 35-10 in snow, clinch AFC East

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills clinched their fifth straight AFC East title with a 35-10 victory over the San Francisco 49ers on a snowy Sunday night

Sports Illustrated

Josh Allen Sets Impressive NFL History in Bills' Dominant Win Over 49ers

What can't the Buffalo quarterback do?

USA Today Sports Media Group

49ers rookie RB Isaac Guerendo finds end zone vs. Bills

During Sunday Night Football against the Bills, Isaac Guerendo punched in his second touchdown of his rookie campaign.

Sports Illustrated

Cris Collinsworth Had the Perfect Metaphor For 49ers’ Costly Fumble vs. Bills

What a wild moment at Highmark Stadium.

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