Many women in their late 40s and 50s notice a gradual change in how their knees, hips, or hands feel. In a 2024 review in the journal Climacteric, researchers at the University of Central Florida College of Medicine and Duke University School of Medicine named that experience the musculoskeletal syndrome of menopause. The researchers estimate more than 70% of women moving through the menopause transition experience these musculoskeletal changes.