Which disease-modifying Alzheimer’s drugs are the most promising?

Liraglutide and semaglutide – known for their use in weight-loss jabs – might help slow Alzheimer’s by reducing brain inflammation. Composite: Guardian Design/Getty

This week England’s health spending watchdog rejected a new Alzheimer’s drug – the second such drug it has turned down this year.

Both donanemab and lecanemab were approved by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA), yet the National Institute for Health and Care Excellence (Nice) said their benefits were too small to justify their costs, while there have also been concerns over potential side-effects – such as brain swelling and bleeding.