There has already been one giant-killing at the fourth-round stage of the FA Cup following Manchester United's exit at the hands of Middlesbrough.
Kidderminster Harriers and Plymouth Argyle both then came close to knocking out Premier League opponents only to be cruelly defeated in extra-time.
Everton made light work of their home tie against Brentford, meanwhile, as Frank Lampard guided the Blues to a 4-1 victory in his first match as manager.