West Coast coach Adam Simpson says he is "furious and disappointed" that some Eagles players visited a local nightclub in the midst of WA's COVID-19 spike.
The Eagles released a statement saying they were aware some players went to a Leederville nightclub last Saturday.
Photos have since emerged of defenders Jackson Nelson and Josh Rotham in attendance just a day after West Coast suffered a 109-point loss to Richmond in Perth.
"I am furious and disappointed with the actions of these players," Simpson said in the club statement.
The Eagles have launched an investigation.
"Given the current environment and the peak in COVID-19 cases in Perth, the club is devastated that some players opted to go out publicly as they have done," a club spokesperson said in the statement.
"The club has gone to great lengths in educating the players around the need to adhere to club guidelines and it is beyond disappointing that they have put themselves in this situation.
"It is particularly disheartening given the strain on player availability at this stage of the season.
"At the earliest opportunity the club will meet with the players concerned."
Simpson and eight players are unavailable for Saturday's match against the Brisbane Lions at the Gabba because of COVID-19.
Rotham has been recalled for the Lions clash, but Nelson is one of the players in the health and safety protocols.
The Eagles have named top-up player Jake Florenca for his AFL debut.
Three other top-up players have been named as emergencies.
Last week's debutant Greg Clark, defender Alex Witherden and ruckman Luke Strnadica have been forced out of the squad after entering the health and safety protocols.
Eagles captain Luke Shuey (hamstring), Willie Rioli (hamstring), and Xavier O'Neill (knee) are out injured, while Hugh Dixon was dropped.
Defender Tom Barrass returns from a hamstring injury and is joined in the team by Luke Foley, Jamaine Jones, Callum Jamieson, Isiah Winder, Rotham, and Florenca.
It is the second time this season the Eagles had to call on supplementary list players.
They are bottom on the ladder, having won only one of seven matches this season.
WA had recorded 10,182 cases in the 24 hours to 8pm on Wednesday, the first time the state had registered more than 10,000 cases in a day.
AAP/ABC