Wales stars Jac Morgan and Scott Baldwin have both been told their seasons are likely to be over following injuries on Wales duty.
The pair both require surgery in a huge double blow for the Ospreys ahead of their European Champions Cup knockout match against Saracens and the chase for a United Rugby Championship play-off spot.
While there is no suggestion the injuries put their World Cup hopes in jeopardy, it is far from ideal in what is a big year for all Welsh players.