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The Conversation
The Conversation
Vinny Negi, Research Scientist in Endocrinology and Metabolism, University of Pittsburgh

Transplanting insulin-making cells to treat Type 1 diabetes is challenging − but stem cells offer a potential improvement

The islets of Langerhans play a crucial role in blood sugar regulation. Fayette A Reynolds/Berkshire Community College Bioscience Image Library via Flickr

Diabetes develops when the body fails to manage its blood glucose levels. One form of diabetes causes the body to not produce insulin at all. Called Type 1 diabetes, or T1D, this autoimmune disease happens when the body’s defense system mistakes its own insulin-producing cells as foreign and kills them. On average, T1D can lead patients to lose an average of 32 years of healthy life.

Current treatment for T1D involves lifelong insulin injections. While effective, patients taking insulin risk developing low blood glucose levels, which can cause symptoms such as shakiness, irritability, hunger, confusion and dizziness. Severe cases can result in seizures or unconsciousness. Real-time blood glucose monitors and injection devices can help avoid low blood sugar levels by controlling insulin release, but they don’t work for some patients.

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