Emerson Royal starts at centre-back for Tottenham at Brighton in the absence of Cristian Romero.
Romero is out for up to five weeks with a hamstring injury and Ange Postecoglou has decided to go with Royal to partner Ben Davies at centre-half.
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Eric Dier replaced Romero at half-time in Saturday's 2-1 win over Everton but Emerson was needed at left-back to cover the suspended Destiny Udogie.
The Brazilian reverts to the middle in a back line made up entirely of full-backs.
Pierre-Emile Hojbjerg comes into the team for Oliver Skipp, who is not in the squad.
"No, no. He's no good," said Postecoglou when asked about Romero.
"He's had a scan, so he'll be out for four or five weeks. Everyone else got through it okay. There's a few sore bodies there but we've had a, sort of, easier training week, last few days anyway, but everyone else is okay."
James Maddison (ankle), Manor Solomon (knee), Ivan Perisic (knee) and Ryan Sessegnon (hamstring) are also still sidelined, while Yves Bissouma will serve the second of a four-match ban.
Confirmed Tottenham XI (4-2-3-1): Vicario; Porro, Royal, Davies, Udogie; Hojbjerg, Sarr; Johnson, Kulusevski, Son; Richarlison
Subs: Forster, Dier, Dorrington, Phillips, Lo Celso, Santiago, Gil, Donley, Veliz
Injured: Romero, Perisic, Maddison, Bentancur, Van de Ven, Sessegnon, Solomon, Whiteman
Suspended: Bissouma
Date and time: 7:30pm GMT on Thursday December 28, 2023
Venue: Amex Stadium
