Antonio Conte has revitalised Tottenham Hotspur's attempt of a top four finish since joining the north London club and will be looking for his side to get three points against Southampton.
Spurs are 3/5 favourites with Grosvenor Sport while Southampton are 19/4 and a draw is 16/5.
The Italian has turned Tottenham's fortunes around greatly with the side going from a mid-table side into solid top four contenders with the north London club only two points behind fourth-place Manchester United with two games-in-hand.