Lumpy Skin Disease (LSD) is a viral disease that predominantly affects cattle. First identified in an outbreak in Zambia in 1929, the disease is caused by the LSD virus (LSDV), a poxvirus of the genus capripoxvirus. Until the 1980s. multiple outbreaks of LSD were confined to the African continent. The first reports of infections outside Africa were in 1989 from Israel. In 2016, LSD was reported from Russia and South-East European nations. In the Indian subcontinent, the disease was initially observed in Bangladesh in 2019, followed by China, India, Nepal, Bhutan, Vietnam, Hong Kong and Myanmar.
The first complete genome sequence of LSDV (Neethling strain) was available in 2001 and suggested a large DNA genome. This strain was originally isolated in Kenya in 1958. Adaptation of poxviruses are dominated by genomic mutations, deletions and recombinations. Subsequent genomes from major outbreaks have provided quite interesting insights into the virus and its evolution.
