Should you get a COVID-19 booster shot now or wait until fall? Two immunologists help weigh the options

Clinical studies show that mixing and matching booster vaccines can lead to a more robust immune response. SDI Productions/E+ via Getty Images

While COVID-19 vaccines continue to be highly effective at preventing hospitalization and death, it has become clear that the protection offered by the current vaccines wanes over time. This necessitates the use of booster shots that are safe and effective in enhancing the immune response against the virus and extending protection.

But when to get a first or second booster, and which shot to choose, are open questions. Many people find themselves unsure whether to wait on new, updated formulations of the COVID-19 vaccines or to mix and match combinations of the original vaccine strains.