UK researchers have homed in on a human gene implicated in thwarting most bird flu viruses from infecting people.
Bird flu chiefly spreads among wild birds such as ducks and gulls and can also infect farmed birds and domestic poultry such as chickens, turkeys and quails.
Although the viruses largely affect birds, they can spill into bird predators, and in rare cases, humans typically in close contact with infected birds.
A team of scientists from the MRC-University of Glasgow Centre for Virus Research studied hundreds of genes normally expressed by human cells, comparing the genes' behaviour during infection with either human seasonal viruses or avian flu viruses.
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They zeroed in on a gene called BTN3A3, expressed both in the upper and the lower human respiratory tract. Nicknamed B-force by the researchers, the gene was found to block the replication of most strains of bird flu in human cells.
However, the gene's antiviral activity failed to protect against seasonal human flu viruses.
This gene is part of a broader defensive apparatus in the human immune arsenal against bird viruses.
All the human influenza pandemics, including the 1918-19 global flu pandemic, were caused by influenza viruses that were resistant to BTN3A3, and therefore the gene appears to be a key factor in whether any bird flu strain has human pandemic potential, the researchers said.
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To be sure, viruses mutate all the time, and this does not mean that bird flu viruses could not evolve to escape the activity of BTN3A3.
Earlier this year, a new H5NI strain of bird flu that transmits easily among wild birds explosively spread into new corners of the globe, infecting and killing a variety of mammal species and raising fears of a human pandemic. So far, only a handful of human cases have been reported to the World Health Organization (WHO).
About 50% of H5N1 strains circulating globally in 2023 are resistant to BTN3A3, said Professor Massimo Palmarini, the corresponding author of the study published in the science journal Nature.
“This is the sort of thing which we should be paying particular attention to as an elevated level of risk,” added Sam Wilson, a co-senior author of the study.
