Mark Nawaqanitawase will make his State of Origin debut for NSW after Casey McLean was ruled out of game two with a leg injury suffered at training.
McLean strained his right quadriceps muscle in the warm-up on Saturday at Central Coast Stadium, where the Blues were holding their final session before flying to Melbourne later that day.
A handful of team staff attended to the Penrith left centre, who came into camp after suffering a minor ankle injury against Wests Tigers last Sunday.
The 20-year-old had been restricted in his training loads this week, but was on track to shake off his ankle issue by Wednesday.
But after going down on Saturday, McLean left the pitch and is expected to be sidelined for between seven and 10 days.