Real Betis will be without defender Luiz Felipe for the second leg of their Europa League last-16 tie against Manchester United on Thursday night.
United hold a 4-1 lead as they head to Spain on Thursday night and are heavy favourites to progress to the quarter-final stage of the competition.
Marcus Rashford's opening goal was cancelled out by Ayoze Perez a week ago, before second-half efforts from Antony, Bruno Fernandes and Wout Weghorst completed the scoreline.
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Manuel Pellegrini has not given up hope that his side can progress from the tie despite the three-goal deficit, though they will have to do it without key defender Felipe.
The Italy international played the full match at Old Trafford last week, but will not be involved this time around, having picked up a hamstring injury.
Felipe is replaced in the squad by teenage defender Felix Garreta, who has made two senior appearances for the club thus far.
There are no other changes from the 23-man squad that travelled to Manchester a week ago.
Real Betis squad:
Bravo, Rui Silva, Dani Martin; Sabaly, Victor Ruiz, Pezzella, Abner, Miranda, Felix; Edgar, Guido Rodriguez, Canales, Luiz Henrique, William Carvalho, Joaquin, Guardado, Rodri, Dani Perez; Juanmi, Borja Iglesias, Willian Jose, Ayoze, Aitor Ruibal.
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