Police say they are concerned for the whereabouts of the two young boys, who are believed to be in each others company.
The PSNI said Kai Mitchell, aged 12 and 14-year-old Brendan-Lee Gault are potentially in the areas of Newtownabbey, Carrickfergus or Coleraine.
In a missing persons appeal posted on Police Mid & East Antrim's Facebook this afternoon, a PSNI spokesperson said: "Police are concerned regarding the whereabouts of the following young persons, believed to be in each others company.