The emergence of the animal tranquilizer xylazine as a fentanyl adulterant, like the emergence of fentanyl as a heroin booster and substitute, has prompted law enforcement officials to agitate for new legal restrictions and criminal penalties. That response is fundamentally misguided, because the threat it aims to address is a familiar consequence of prohibition, which creates a black market in which drug composition is highly variable and unpredictable. Instead of recognizing their complicity in maintaining and magnifying that hazard, drug warriors always think the answer is more of the same.
Xylazine was first identified as a fentanyl adulterant in 2006, and today it is especially common in Puerto Rico, Philadelphia, Maryland, and Connecticut. In Philadelphia between 2010 and 2015, according to a 2021 BMJ article, xylazine was detected in less than 2 percent of drug-related deaths involving heroin and/or fentanyl. Its prevalence in such cases had risen to 31 percent by 2019. According to a 2022 Cureus report, "up to 78%" of illicit fentanyl sold in Puerto Rico and Philadelphia contains xylazine. In 2022, the Drug Enforcement Administration (DEA) reports, xylazine was detected in 23 percent of fentanyl powder and 7 percent of fentanyl pills analyzed by its laboratories.
