The San Francisco 49ers will bookend the NFL 's largest ever international slate, playing the 2026 season opener in Melbourne against the NFC West rival Los Angeles Rams and facing the Minnesota Vikings in Week 11 in Mexico City.
The league had long ago announced the Melbourne matchup, its first game in Australia, and completed the unveiling on Wednesday morning, the day before the full schedule for all 32 teams will be released. The 49ers will be the road team for the Thursday night game on Sept. 10 against the Rams on Netflix. That will actually take place on Friday morning in Melbourne.
In Mexico City, the 49ers will be the home team for a Sunday night game on Nov. 22 against the Vikings, who last year played the NFL's first international multi-city road trip with a game in Dublin in Week 4 followed by a game in London in Week 5. The Vikings were the road team in both of those games last year, too.
