Munich Airport suspended all flights on Tuesday morning due to freezing rain.
All flights were either cancelled or postponed between 6am and noon (5am to 11am GMT), with the airport warning that many flights scheduled for later in the day might also be affected by the severe weather conditions.
The airport, Germany's second-largest, announced the temporary shutdown on Monday night as a result of weather forecasts for Tuesday.
“The operating areas will be de-iced in the first half of the day. The plan is to allow air traffic to resume from midday," the airport said on its website.
“However, it can be assumed that the majority of flights will also have to be cancelled during the rest of the day for safety reasons."
Destinations of cancelled flights included places like Paris, Madrid and Istanbul.
It came after all flights at the airport were grounded on Saturday following heavy snowfall in the city and in Germany's southern state of Bavaria.
Road traffic and train connections were also hampered by the weather conditions.
Two people died in a collision between a car and a tractor-trailer in upper Bavaria, after their car skidded under the rear of a truck.
The truck had come to a stop across the highway overnight due to frozen rain on the highway's surface, reported news agency DPA.
The A99 near Munich was also shut down in both directions after 13 vehicles were involved in a mass accident, DPA reported. There was no immediate information about possible injuries.
Train operator Deutsche Bahn said traffic in the Munich region would be affected for several days.
“At present, access to Munich's main station is severely restricted. Only a few long-distance trains are therefore running to and from Munich," it said on its website on Tuesday.
Southern Germany as well as neighbouring Austria and Switzerland have been experiencing heavy snowfall which has affected public transport all over the region.