Alejandro Garnacho could be a doubt for Manchester United's trip to Newcastle United in April after being ruled out with an ankle ligament injury for several weeks.
The 18-year-old was introduced in the 73rd minute and spent a number of minutes receiving treatment following a challenge by Kyle Walker-Peters.
Garnacho was later replaced by Fred before leaving Old Trafford on crutches. He will miss the Red Devils' Europa League Round of 16 second leg at Real Betis on Thursday, and Sunday's FA Cup quarter-final against Fulham.