Life as we know it needs water, but life as we don't know it may run on concentrated sulfuric acid.
The chemistry of life as we know it wouldn't work in a place like the huge Saturn moon Titan, where it's so cold that ice behaves more like rock, or in the acidic clouds of Venus. But a different chemistry, which built all the requisite pieces out of different materials, might have a shot. Imagine cells that use methane, sulfuric acid, or even molten rock the way your cells use water.
