Gabriel Martinelli's hat-trick saw Premier League leaders Arsenal overcome an early scare to beat Championship strugglers Portsmouth 4-1 in the FA Cup third round.
Portsmouth took a shock lead less than three minutes in through skipper Colby Bishop, but Andre Dozzell's own goal quickly levelled it.
Martinelli then took over, scoring either side of a missed penalty from Noni Madueke before completing his hat-trick in the 72nd minute.
Danny Welbeck scored the pick of the goals to dump out managerless Manchester United as Brighton won 2-1 at Old Trafford.
Brajan Gruda nodded in the opener 12 minutes in, and Welbeck rifled a left-footed strike into the top corner after the hour.
Benjamin Sesko pulled one back but United youngster Shea Lacey was sent off for a second bookable offence late on.
Willy Gnonto and Ao Tanaka scored within four minutes of one another as Leeds came from behind to beat Derby 3-1.
Ben Brereton Diaz put the hosts ahead after Joel Piroe's first-half penalty was saved, but after Gnonto and Tanaka turned it around, James Justin added a third.
West Ham's new £26million striker Taty Castellanos scored an extra-time winner to see off QPR 2-1 after Richard Kone had cancelled out Crysencio Summerville's opener.
Louis Reed scored twice against his former club as League One Mansfield upset Championship side Sheffield United with a 4-3 win at Bramall Lane, having led 4-1 before Patrick Bamford and a Nathan Moriah-Welsh own goal gave the Blades hope.
Jovon Makama's hat-trick powered Championship strugglers Norwich to a 5-1 win over Walsall, with Matej Jurasek and Tony Springett also on target.
Hull saw off Blackburn 4-3 on penalties after a poor goalless draw over 120 minutes, with Dillon Phillips denying Yuki Ohashi and Moussa Baradji from the spot.
Ollie Bostock hit the winning penalty as West Brom beat Swansea 6-5 on penalties after their match finished 2-2 in south Wales.
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