World champions South Africa will come to the Aviva Stadium in November to kick off Ireland's autumn series - less than a year out from the side's World Cup 2023 meeting at the Stade de France.
Australia and Fiji will also face Andy Farrell's men at the Lansdowne Road venue in the November window.
With Ireland also travelling to New Zealand for three Tests against the All Blacks in July, Farrell will relish the opportunity to see how his players perform against such top level opposition over the next six months.