Nurses have announced details of a 48-hour walkout that will include A&E and cancer staff for the first time.
Hospitals across England will face unprecedented disruption as the strikes takes place in a fortnight.
The Royal College of Nursing announced the fresh action after its members rejected the Government’s pay offer.
It will now hold a vote of members on a further six months of possible strikes across England.
The walkouts may be timed to coincide with industrial action by junior doctors, maximising disruption to the NHS.
The RCN tonight announced its members had rejected the proposed pay deal, with 54% opposed and 46% in support. The turnout was 61%.
The wage deal included a 5% pay rise this year and a cash payment for last year.
Rishi Sunak, who had boasted that he was bringing an end to this winter’s wave of industrial action, now faces a summer of discontent.
RCN general secretary Pat Cullen, who had recommended the deal to members, tonight wrote to Health Secretary Steve Barclay to seek an urgent re-opening of talks.
If you can't see the poll, click here
The country's largest nursing union said it will hold a round-the-clock 48-hour strike from 8pm on Sunday 30 April to 8pm on Tuesday 2 May, including the Bank Holiday Monday.
It will be the most intense action to date as it will involve nursing staff working in emergency departments, intensive care units, cancer care and other services that were previously exempt.
In her letter to Mr Barclay, Ms Cullen wrote: "What has been offered to date is simply not enough. The government needs to increase what has already been offered and we will be highly critical of any move to reduce it.
"Since our talks in February, we have seen the pressures on the NHS continue to increase. The crisis in our health and care services cannot be addressed without significant action that addresses urgent recruitment and retention issues and nursing pay to bring this dispute to a close urgently."
The union leader added: "Until there is a significantly improved offer, we are forced back to the picket line.
"Meetings alone are not sufficient to prevent strike action and I will require an improved offer as soon as possible. In February, you opened negotiations directly with me and I urge you to do the same now.
"After a historic vote to strike, our members expect a historic pay award."
Hospital trusts have urged ministers to avert the fresh strikes by nurses.
Adam Brimelow of NHS Providers said: "It’s really important that the unions and government find a way through this to prevent more strikes and let the NHS focus on its big challenges including cutting waiting lists and transforming services, instead of having to resort to ‘all hands on deck’ just to get through the day."
Members of Unison, which represents health workers including ambulance staff, voted overwhelmingly to accept the pay offer.
The union announced that 74% of those who voted backed the deal. The turnout was 52% among Unison's 288,000 members in England.
The 48-hour strike starting at 8pm on Sunday 30 April will take place at the following locations:
England
East Midlands
Derbyshire Community Health Services NHS Foundation Trust
Derbyshire Healthcare NHS Foundation Trust
East Midlands Ambulance Service NHS Trust
Kettering General Hospital NHS Foundation Trust
NHS Derby and Derbyshire ICB
NHS Nottingham and Nottinghamshire ICB
Northamptonshire Healthcare NHS Foundation Trust
Nottingham University Hospitals NHS Trust
Nottinghamshire Healthcare NHS Foundation Trust
Eastern
Cambridge University Hospital NHS Foundation Trust
Cambridgeshire and Peterborough NHS Foundation Trust
Cambridgeshire Community Services NHS Trust
East Suffolk and North Essex NHS Foundation Trust
Hertfordshire Community NHS Trust
NHS Hertfordshire and West Essex ICB
NHS Mid and South Essex ICB
NHS Norfolk and Waveney ICB
NHS Suffolk and North East Essex ICB
Norfolk and Norwich University Hospitals NHS Foundation Trust
Norfolk and Suffolk NHS Foundation Trust
Norfolk Community Health and Care NHS Trust
Royal Papworth Hospital NHS Foundation Trust
West Suffolk NHS Foundation Trust
London
Great Ormond Street Hospital for Children NHS Foundation Trust
Guys and St Thomas NHS Foundation Trust
Hounslow and Richmond Community Healthcare NHS Trust
Imperial College Healthcare NHS Trust
Kings College Hospital NHS Foundation Trust
NHS North Central London ICB
NHS South West London ICB
Royal Marsden NHS Foundation Trust
St George's University Hospitals NHS Foundation Trust
Tavistock and Portman NHS Foundation Trust
University College London Hospitals NHS Foundation Trust
North West
Alder Hey Children's NHS Foundation Trust
Bridgewater Community Healthcare NHS Foundation Trust
Cheshire and Wirral Partnership NHS Foundation Trust
Countess of Chester Hospital NHS Foundation Trust
Lancashire Teaching Hospitals NHS Foundation Trust
Liverpool Heart and Chest Hospital NHS Foundation Trust
Liverpool University Hospitals NHS Foundation Trust
Liverpool Women's NHS Foundation Trust
Mersey Care NHS Foundation Trust
Mid Cheshire Hospitals NHS Foundation Trust
NHS Cheshire and Merseyside ICB
NHS Lancashire and South Cumbria ICB
North West Ambulance Service NHS Trust
St Helens and Knowsley Teaching Hospitals NHS Trust
Tameside and Glossop Integrated Care NHS Foundation Trust
The Christie NHS Foundation Trust
The Clatterbridge Cancer Centre NHS Foundation Trust
The Walton Centre NHS Foundation Trust
Wirral Community Health and Care NHS Foundation Trust
Wirral University Teaching Hospital NHS Foundation Trust
Wrightington Wigan and Leigh NHS Foundation Trust
Northern
Country Durham and Darlington NHS Foundation Trust
Gateshead NHS Foundation Trust
North of England Commissioning Support (NECS)
North East Ambulance Service NHS Trust
Northumbria Healthcare NHS Foundation Trust
South Tees Hospitals NHS Foundation Trust
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
University Hospitals of Morecambe Bay NHS Foundation Trust
South East
East Sussex Healthcare NHS Trust
Kent Community Health NHS Foundation Trust
NHS Kent and Medway ICB
NHS Surrey Heartlands ICB
Queen Victoria Hospital NHS Foundation Trust
South East Coast Ambulance Service
Sussex Community NHS Foundation Trust
Sussex Partnership NHS Foundation Trust
University Hospitals Sussex NHS Foundation Trust
Oxford Health NHS Foundation Trust
Oxford University Hospitals NHS Foundation Trust
Portsmouth Hospitals NHS Trust
Royal Berkshire NHS Foundation Trust
Solent NHS Trust
South Central Ambulance Services NHS Foundation Trust
Southern Health NHS Foundation Trust
University Hospital Southampton NHS Foundation Trust
South West
Avon and Wiltshire Mental Health Partnership NHS Trust
Cornwall Partnership NHS Foundation Trust
Devon Partnership NHS Trust
Dorset County Hospital NHS Foundation Trust
Dorset Healthcare University NHS Foundation Trust
Gloucestershire Health and Care NHS Foundation Trust
Gloucestershire Hospitals NHS Foundation Trust
Great Western Hospitals NHS Foundation Trust
NHS Bath, North East Somerset, Swindon and Wiltshire ICB
NHS Devon ICB (One Devon)
NHS Dorset ICB (One Dorset)
NHS Gloucestershire ICB (One Gloucestershire)
North Bristol NHS Trust
Royal Cornwall Hospitals NHS Trust
Royal Devon University Healthcare NHS Foundation Trust
Royal United Hospitals Bath NHS Foundation Trust
Salisbury NHS Foundation Trust
Somerset NHS Foundation Trust
South Western Ambulance Service NHS Foundation Trust
Torbay and South Devon NHS Foundation Trust
University Hospitals Bristol and Weston NHS Foundation Trust
University Hospitals Dorset NHS Foundation Trust
University Hospitals Plymouth NHS Trust
West Midlands
Birmingham Women's and Children's NHS Foundation Trust
Dudley Integrated Health and Care NHS Trust
Herefordshire and Worcestershire Health and Care NHS Trust
Midlands and Lancashire CSU
Midlands Partnership NHS Foundation Trust
NHS Birmingham and Solihull ICB (BSol ICB)
NHS Black Country ICB
Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust
Shropshire Community Health NHS Trust
The Royal Orthopaedic Hospital NHS Foundation Trust
University Hospitals Birmingham NHS Foundation Trust
Worcestershire Acute Hospitals NHS Trust
Yorkshire and the Humber
Barnsley Hospital NHS Foundation Trust
Bradford Teaching Hospitals NHS Foundation Trust
Harrogate and District NHS Foundation Trust
Leeds Community Healthcare NHS Trust
NHS North West Yorkshire ICB
Sheffield Children's NHS Foundation Trust
Sheffield Health and Social Care NHS Foundation Trust
Sheffield Teaching Hospitals NHS Foundation Trust
The Leeds Teaching Hospitals NHS Trust
York and Scarborough Teaching Hospitals NHS Foundation Trust
National employers
Health Education England
NHS Blood and Transplant
NHS England
NHS Resolution
