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The Conversation
The Conversation
Marc Zimmer, Professor of Chemistry, Connecticut College

Genome sequencing is rewriting the history of disease outbreaks – but without social context, it can tell only part of the story

A pathogen's genome acts as a biological record of where it came from and how it spread. Westend61/Getty Images

Fingerprinting transformed police investigations by making it possible to place a suspect at a crime scene with physical evidence. Similarly, genome sequencing has changed how disease detectives study outbreaks by allowing them to read a pathogen’s genes as a biological record of where it came from and how it spread.

One way to think about sequencing is to imagine a virus or bacteria’s genome as a recipe book. Each gene is a recipe for making a protein. When scientists sequence a pathogen, they read the order of the genetic letters in those recipes.

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