Wales travel to Twickenham for the chance to build on their incredible win against Scotland after a two-week break.
While England are the strong favourites at 1/7 with Grosvenor Sport, Wales are 17/4 and a draw is 30/1.
Wayne Pivac's side is still heavily affected with injuries but that still did not stop them overseeing Scotland 20-17 at the Millennium Stadium in round two.
