Owen Farrell suffered an injury while training with his club Saracens this week, ruling him out of his return to club action this weekend after missing the last two months with an ankle problem.
He was set to make his return to club action against London Irish in the Challenge Cup this weekend after suffering the injury against Australia in November.
England are set to join up at a training camp in Brighton on Monday ahead of their Six Nations opener against Scotland at Murrayfield on February 5.