Drugs that target advanced breast cancer could be beneficial for patients with a rare cancer that affects parts of the digestive system, a trial has found.
Tucatinib and trastuzumab work by blocking a protein known as human epidermal growth factor receptor 2 (HER2) in cancer cells to stop them from growing or spreading.
The drugs are recommended by the National Institute for Health and Care Excellence (Nice) as an option for patients with HER2‑positive locally advanced or metastatic breast cancer who have had two or more anti‑HER2 treatment therapies.
Researchers explored the use of the treatment for other cancers, including that of the bile ducts.
Bile duct cancer, also known as cholangiocarcinoma, affects the small tubes that connect different organs, including the liver and gallbladder.
The phase two trial included 217 patients with different tumours that had spread in the body, and that had signs of changes to HER2.
They were given 21-day cycles of tucatinib tablets twice every day and trastuzumab intravenously once every three weeks.
Researchers found cancer shrank in 22.2% of patients overall. However, among the 30 patients with bile duct cancer, cancer shrank in 46.7%.
Dr Yoshiaki Nakamura, of the National Cancer Centre Hospital East in Kashiwa, Japan, said: “This chemotherapy-free combination was shown to be safe and well-tolerated. Very few patients had to stop treatment due to side effects.
“The results of the study show variable effects across different tumour types.
“However, patients with HER2-positive metastatic bile duct cancer and HER2-mutated metastatic breast cancer experienced clinically relevant overall response rates.
“These results support inclusion of this drug combination in guidelines for patients with previously treated HER2-postive bile duct cancer.
“The results for the patients with metastatic breast cancer suggest that those with HER2-mutated tumours could also benefit from these HER2-targeted treatments.”
According to Liver Cancer UK, about 2,200 people in England are diagnosed with bile duct cancer every year.
The findings of the trial will be presented at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona on Thursday.
Dr Tim Greten, co-chair of the EORTC-NCI-AACR Symposium and senior investigator at the Centre for Cancer Research at the National Cancer Institute, added: “Cancer trials often focus on a particular type of tumour, such as breast or bowel cancer.
“This trial was designed to focus on the molecular make-up of the tumour, regardless of where it is in the body.
“This means that researchers can include rare forms of the disease, such as bile duct cancer, that urgently need more treatment options.
“HER2 has been well-studied in breast cancer, but we are starting to see that it could be a useful target for treating other cancers.
“This study suggests that using two drugs that both target HER2 could prove beneficial for a wider group of breast cancer patients and for some patients with bile duct cancer. However, this is an early trial, and we need to see further research to confirm these results.”
