Dele Alli makes his first start for Everton after his game-changing second half performance against Crystal Palace.
Frank Lampard has made six changes as he takes control of his first league game in months without the threat of relegation weighing heavily on his mind.
Thursday night's dramatic comeback victory secured the club's Premier League survival and removed all of the nerves from the trip to the Emirates.
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And, as a result, he has mixed up his starting line up against an Arsenal side that has a slim chance of Champions League qualification.
That means a start for Alli, with Asmir Begovic, Jonjoe Kenny, Jarrad Branthwaite, Tom Davies and Demarai Gray all coming into the first eleven. Richarlison is not included in the matchday squad, while Jordan Pickford, Seamus Coleman, Vitalii Mykolenko, Andre Gomes and Anthony Gordon also miss out.
The inclusion of Begovic - whose contract was recently extended into next year - removes the spectacle of Jordan Pickford facing his supposed main challenger for the England goalkeeper spot, Aaron Ramsdale.
Davies is set to play his first minutes after months out with injury while Branthwaite returns after the red card he picked up against Brentford ruled him out of the Palace tie.
Starting XI: Begovic, Kenny, Holgate, Keane, Branthwaite, Davies, Doucoure, Alli, Iwobi, Calvert-Lewin, Gray
Subs: Lonergan, Mykolenko, Coleman, Welch, van de Beek, Price, Gordon, Tosun, Dobbin
