A flat tire usually means one thing: stop driving! But there's an important exception. If your vehicle is equipped with run-flat tires, a loss of air pressure doesn't necessarily mean you're stranded on the side of the road.
Thanks to reinforced sidewalls that allow run-flat tires to temporarily support the vehicle's weight after losing air, the driver can reach a safe location or tire shop. For a conventional tire, however, the answer is much simpler: don't drive on it.