Newcastle's unbeaten St James' Park record came to an end at the hands of quadruple-chasing Liverpool. The Magpies started brightly, but it was Liverpool who had the first efforts on goal, Diego Jota going close and Virgil van Dyke firing over from a corner.
The visitors took the lead through Naby Keita midway through the half after a flowing move. United were furious over a challenge by James Milner on Fabian Schar in the build-up, but VAR ruled the former Newcastle man had won the ball.
Allan Saint-Maximin sent one wide as the home side looked to get back into the game, but Liverpool were dangerous at the other end, with Mane shooting at Dubravka when it a good position. Miguel Almiron did well to get free and beat Alisson, but the Paraguay forward was correctly riuled offside.