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LiveScience
LiveScience
Emily Cooke

Brain inflammation may drive mood changes in Alzheimer's

Brain Disease Anxiety Depression Protein the University of Pittsburgh
Microglia (in pink) are immune cells that trigger inflammation in the central nervous system in response to tissue injury or infection. (Image credit: Artur Plawgo via Getty Images)

Extreme mood changes associated with Alzheimer's disease may be partially driven by brain inflammation, new research suggests. 

Historically, the prevailing theory for what causes Alzheimer's disease was that a gradual buildup of abnormal proteins called amyloid-beta and tau in the brain triggers a cascade of events, leading to nerve damage, the death of brain cells, and symptoms of cognitive decline and mood problems. 

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