After suffering just their third defeat of the season against PSV in the Europa League last week, top spot in group A is on the line as they welcome Zurich to Emirates Stadium on Thursday.
Mikel Arteta has relied on the same core group of players in Premier League action and their Europa League battles so far this season, with Granit Xhaka and Bukayo Saka among the players to feature in all 17 of Arsenal's games this campaign.
The latter of those names may be afforded a rest though after Saka limped off in the first half of the rampant victory over Forest at the weekend with Reiss Nelson replacing him and staking his claim for a more consistent role in the Arsenal team after scoring twice and grabbing an assist.