A 50-year-old man on weekly semaglutide looked at his new injection pen after taking his 2.4 mg dose, saw liquid still sitting in the cartridge, and assumed the shot had failed. He kept injecting until the pen was empty. The total came to 9.6 mg, four times his prescribed weekly dose.
What happened next did not match the textbook. Two days later, he developed generalized burning skin sensations and marked weakness, with no nausea, no vomiting, and no abdominal pain at all. The case was published in 2026 in JACEP Open, the open-access journal of the American College of Emergency Physicians, and is freely available through PubMed Central.
