More than five weeks into Operation Epic Fury, the U.S.-led military campaign against Iran that began Feb. 28, 2026, a range of advanced weapons has shaped the conflict's deadly course. U.S. and allied forces have unleashed precision strikes on Iranian military targets, while Iran has responded with ballistic missiles, drones and air defenses that claimed at least one American aircraft.
Here are 10 of the most lethal weapons used so far, based on U.S. Central Command reports, independent analyses and public footage as of April 4. Lethality is assessed by destructive power, frequency of use, confirmed impacts and strategic effect.
