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The Latest Breaking News from 49ers

Isaac Guerendo Could Be Most Valuable Fantasy Football Asset Over Jordan Mason With Christian McCaffrey Injured

Isaac Guerendo and Jordan Mason are both top waiver wire adds this week with Christian McCaffrey hurt.

Sports Illustrated

Josh Allen Had Classy Answer About His Favorite TD in Win Against 49ers

The QB had a nice shoutout for a teammate.

Sports Illustrated

49Ers' Mccaffrey Suffers Potentially Season-Ending Knee Injury

San Francisco 49ers face challenges as running back Christian McCaffrey sustains a potentially season-ending knee injury.

Top News

Bills' Amari Cooper Explains How Lateral TD to Josh Allen Came to Fruition

Amari Cooper explained his decision to lateral to Josh Allen during the Bills' surreal touchdown vs. the 49ers.

Sports Illustrated

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Buffalo Bills clinch fifth straight AFC title in the snow

Josh Allen scored touchdowns passing, rushing and receiving as the Bills beat the San Francisco 49ers 35-10.

The Independent UK

Josh Allen, Sean McDermott Gleefully Celebrate Bills Win vs. 49ers With Snow Angels

Josh Allen and Sean McDermott hit snow angels on the field in celebration of the Bills' Week 13 win.

Sports Illustrated

Christian McCaffrey Suffered Likely Season-Ending Knee Injury vs. Bills

San Francisco may have lost more than just a game on Sunday night.

Sports Illustrated

Christian McCaffrey feared to have suffered season-ending knee injury

San Francisco 49ers running back Christian McCaffrey is feared to have suffered a season-ending PCL injury vs. the Buffalo Bills.

USA Today Sports Media Group

Josh Allen has TDs passing, rushing and receiving as Bills rout 49ers 35-10 in snow, clinch AFC East

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills clinched their fifth straight AFC East title with a 35-10 victory over the San Francisco 49ers on a snowy Sunday night

The Independent UK

Josh Allen Sets Impressive NFL History in Bills' Dominant Win Over 49ers

What can't the Buffalo quarterback do?

Sports Illustrated

49ers rookie RB Isaac Guerendo finds end zone vs. Bills

During Sunday Night Football against the Bills, Isaac Guerendo punched in his second touchdown of his rookie campaign.

USA Today Sports Media Group

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Sports Illustrated

Cris Collinsworth Had the Perfect Metaphor For 49ers’ Costly Fumble vs. Bills

What a wild moment at Highmark Stadium.

USA Today Sports Media Group

Josh Allen threw a touchdown pass to himself on ridiculous Bills’ lateral play

Yes, really!

Sports Illustrated

Patrick Mahomes Had Three-Word Reaction to Josh Allen’s Ridiculous TD vs. 49ers

This may have been the play of the year.

Sports Illustrated

Bills, Josh Allen Pull Off Incredible Lateral Touchdown in Snow vs. 49ers

That was wild.

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Sports Illustrated

Bills Fan Hilariously Tries to Knock Down 49ers’ FG Attempt by Throwing Snowball

This was so close.

USA Today Sports Media Group

Christian McCaffrey ruled out of 49ers’ game vs Bills

San Francisco running back Christian McCaffrey was officially ruled out of the 49ers' Sunday Night Football contest at the Buffalo Bills.

Sports Illustrated

NFL World Reacts to 49ers' Christian McCaffrey's Apparent Knee Injury vs. Bills

A brutal blow to one of the league's best.

USA Today Sports Media Group

Fred Warner returns vs Bills despite cramps

San Francisco 49ers linebacker Fred Warner exited with cramps, but then later returned in the first half vs. the Buffalo Bills.

USA Today Sports Media Group

Christian McCaffrey leaves 49ers game vs Bills with knee injury

San Francisco star running back Christian McCaffrey exited the 49ers Sunday Night Football game against the Bills with a knee injury.

USA Today Sports Media Group

49ers injury update: DL Kevin Givens (chest) questionable to return vs. Bills

The 49ers defensive line depth will continue to be tested on Sunday Night Football against the Bills.

USA Today Sports Media Group

49ers injury news: QB Brock Purdy officially active vs. Bills

Brock Purdy is officially back.

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