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Medical Daily
Medical Daily
Amelia Palmer

Your Astrocytes Have Their Own Birthday, and for Some People It Decides Whether APOE4 Becomes Alzheimer's

A surprised patient reacts as researchers examine his blood, highlighting how a new AI model could estimate the biological age of individual cell types. (Credit: Editorial Illustration via AI)

Your driver's license records one age. A machine learning model trained on more than 7,000 blood proteins can now estimate more than 40 others, one for each cell type it can detect, and they do not agree with each other or with the license.

That is the finding from a Stanford-led team whose work appeared in Nature Medicine on June 15. Drawing on plasma from 60,542 individuals across three cohorts, the researchers built separate biological-age estimates for cell types spanning neuronal, immune, glial, endocrine, epithelial, and musculoskeletal origins.

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