Ibrahima Konate starts for Liverpool as Jordan Henderson misses out entirely against Napoli.
Konate has started just one other game for the Reds this season - the 7-1 hammering of Rangers last month - but is back in the side next to Virgil van Dijk as the Reds aim to finish their Group A campaign on a high against the Serie A leaders.
It's four changes in total for the Reds as Kostas Tsimikas also comes into the defence at left-back, while Curtis Jones starts in what could be an advanced midfield position.